1,1-Difluoro-5-azaspiro[2.4]heptane hydrochloride

CAS No. 1215071-12-7
Cat. No. CS-0052765
Purity≥97%
MDL No.None

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1,1-Difluoro-5-azaspiro[2.4]heptane hydrochloride|CS-0052765

Structure of 1215071-12-7

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Description

This difluorinated spirocyclic amine features a rigid, electron-deficient core ideal for probing conformational preferences in medicinal chemistry. The hydrochloride salt enhances solubility and stability, enabling straightforward incorporation into synthetic routes targeting CNS-active compounds and fluorinated heterocycles.

Application

1,1-Difluoro-5-azaspiro[2.4]heptane hydrochloride serves as a rigid, conformationally constrained building block for medicinal chemistry campaigns, enabling the introduction of fluorinated spirocyclic motifs with enhanced metabolic stability. The difluoromethylene group imparts strong electron-withdrawing character and improves membrane permeability, while the protonated amine enhances solubility and facilitates salt formation. Its robust bench stability and compatibility with standard coupling reactions make it ideal for rapid library synthesis and structure–activity relationship studies.

General Information

CAS No. 1215071-12-7
Cat. No. CS-0052765
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₀ClF₂N
Molecular Weight 169.60
Synonym(s) 2,2-difluoro-5-azaspiro[2.4]heptane
SMILES Cl.FC1(F)CC11CCNC1

Computational Chemistry Data

TPSA 12.03
LogP 1.4269
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Building Blocks Skeleton Spirol Rings compounds

Key Words

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1,1-Difluoro-5-azaspiro[2.4]heptane hydrochloride

CAS No. 1215071-12-7

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