3-Cyclopropyl-1-methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole

CAS No. 1257637-82-3
Cat. No. CS-0241392
Purity≥98%
MDL No.None

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3-Cyclopropyl-1-methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole|CS-0241392

Structure of 1257637-82-3

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Description

3-Cyclopropyl-1-methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is a bench-stable boronate reagent featuring a sterically accessible boronate handle. This pyrazole scaffold integrates readily into cross-coupling reactions under mild conditions, delivering efficient access to functionalized heterocycles with predictable regiochemistry.

Application

3-Cyclopropyl-1-methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole serves as a stable, bench-ready boronate building block for Suzuki-Miyaura cross-coupling reactions. The tetramethylboronate moiety enables efficient C–C bond formation under mild conditions, while the cyclopropyl and methyl substituents provide structural rigidity and enhanced metabolic stability. This compound functions reliably in the construction of diverse pyrazole-based scaffolds relevant to medicinal chemistry and process-scale synthesis.

General Information

CAS No. 1257637-82-3
Cat. No. CS-0241392
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₂₁BN₂O₂
Molecular Weight 248.13
Synonym(s) 3-cyclopropyl-1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
SMILES CC1(C)C(C)(C)OB(C2=CN(C)N=C2C3CC3)O1

Computational Chemistry Data

TPSA 36.28
LogP 1.5967
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 2

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Key Words

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3-Cyclopropyl-1-methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole

CAS No. 1257637-82-3

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