CRBN ligand-880

CAS No. 1267337-47-2
Cat. No. CS-0343245
Purity≥98%
MDL No.MFCD19372740

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Structure of 1267337-47-2

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Description

3-(4-Bromophenyl)piperidine-2,6-dione features a brominated phenyl group attached to a piperidinedione core, delivering enhanced electron-withdrawing character and steric bulk. This structural motif enables robust integration into bioactive scaffolds, particularly in medicinal chemistry campaigns targeting CNS modulators and kinase inhibitors. The compound exhibits high stability under standard bench conditions and facilitates efficient derivatization through the carbonyl functionalities.

Application

3-(4-Bromophenyl)piperidine-2,6-dione serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its brominated aryl group enables palladium-catalyzed cross-coupling reactions, while the diketone framework supports facile functionalization at both nitrogen and carbon centers. The compound exhibits good bench stability and compatibility with standard synthetic protocols, facilitating efficient access to complex scaffolds in medicinal chemistry campaigns.

General Information

CAS No. 1267337-47-2
Cat. No. CS-0343245
Purity ≥98%
MDL No. MFCD19372740
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₁₀BrNO₂
Molecular Weight 268.11
Synonym(s) None
SMILES O=C1NC(=O)C(C2=CC=C(Br)C=C2)CC1

Computational Chemistry Data

TPSA 46.17
LogP 2.0817
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science PROTAC Ligands for E3 Ligase

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

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CRBN ligand-880

CAS No. 1267337-47-2

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