(2-(Trifluoromethyl)pyrimidin-5-yl)boronic acid

CAS No. 1308298-23-8
Cat. No. CS-D0474
Purity≥95%
MDL No.MFCD10696932

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(2-(Trifluoromethyl)pyrimidin-5-yl)boronic acid|CS-D0474

Structure of 1308298-23-8

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Description

This boronate moiety features a trifluoromethylpyrimidine scaffold, delivering enhanced metabolic stability and electron-deficient character. It integrates readily into Suzuki-Miyaura cross-coupling reactions under standard conditions, enabling efficient access to functionalized heteroaryl architectures in medicinal chemistry and materials science.

Application

(2-(Trifluoromethyl)pyrimidin-5-yl)boronic acid serves as a versatile building block in cross-coupling reactions, enabling efficient construction of biologically relevant pyrimidine derivatives. Its trifluoromethyl group enhances metabolic stability and modulates electronic properties, while the boronic acid functionality facilitates reliable Suzuki-Miyaura coupling under standard conditions. The compound exhibits excellent bench stability, ease of handling, and compatibility with diverse functional groups, making it ideal for medicinal chemistry and process development workflows.

General Information

CAS No. 1308298-23-8
Cat. No. CS-D0474
Purity ≥95%
MDL No. MFCD10696932
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄BF₃N₂O₂
Molecular Weight 191.90
Synonym(s) 2-(trifluoromethyl)pyrimidin-5-ylboronic acid
SMILES OB(C1=CN=C(C(F)(F)F)N=C1)O

Computational Chemistry Data

TPSA 66.24
LogP -0.8248
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Boronic Acid And Its Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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(2-(Trifluoromethyl)pyrimidin-5-yl)boronic acid

CAS No. 1308298-23-8

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