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Structure of 127199-14-8
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This fluorinated cyclopropanecarboxylic acid features a strained three-membered ring with stereocontrolled fluorine incorporation, delivering enhanced metabolic stability and conformational rigidity. The (1S,2S) configuration imparts distinct stereoelectronic properties, making it valuable for probing bioactive molecule scaffolds in medicinal chemistry and as a chiral building block in asymmetric synthesis.
(1S,2S)-2-Fluorocyclopropanecarboxylic acid serves as a stable, enantiomerically pure building block for the synthesis of fluorinated cyclopropane-containing molecules. Its constrained ring structure imparts distinct conformational rigidity, enabling precise spatial presentation of functional groups in medicinal chemistry applications. The carboxylic acid functionality facilitates straightforward derivatization via amide, ester, or acyl chloride formation, while the fluorine atom enhances metabolic stability and modulates electronic properties. This compound exhibits excellent bench stability and is compatible with standard coupling reactions, making it a reliable scaffold for targeted molecular design.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H302-H314-H335
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Precautionary Statements : P260-P264-P270-P271-P280-P301+P330+P331-P304+P340-P363-P405-P501
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Lot numbers can be found on the outside label of a product: