2,2-Difluoropropane-1,3-diamine dihydrochloride

CAS No. 133186-53-5
Cat. No. CS-0038484
Purity≥97%
MDL No.MFCD23378436

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2,2-Difluoropropane-1,3-diamine dihydrochloride|CS-0038484

Structure of 133186-53-5

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General Information

CAS No. 133186-53-5
Cat. No. CS-0038484
Purity ≥97%
MDL No. MFCD23378436
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃H₁₀Cl₂F₂N₂
Molecular Weight 183.03
Synonym(s) 2,2-DIFLUOROPROPANE-1,3-DIAMINE-2HCL
SMILES NCC(F)(F)CN.[H]Cl.[H]Cl

Description

This difluorinated diamine dihydrochloride delivers a robust, moisture-tolerant scaffold for bioconjugation and medicinal chemistry. The gem-difluoro substitution enhances metabolic stability while the diamine core provides dual functional handles for coupling. This salt form ensures high solubility and ease of handling under standard conditions.

Application

2,2-Difluoropropane-1,3-diamine dihydrochloride serves as a stable, bench-ready diamine building block for the synthesis of fluorinated heterocycles and peptide-like scaffolds. Its difluoromethyl group enhances metabolic stability and modulates lipophilicity, while the protonated amine functionalities facilitate salt formation and purification. The compound enables efficient coupling reactions and functions effectively in solid-phase synthesis workflows, offering predictable reactivity and compatibility with standard protecting group strategies.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 52.04
LogP 0.3827
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Fatty chain compounds

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2,2-Difluoropropane-1,3-diamine dihydrochloride

CAS No. 133186-53-5

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