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Structure of 22510-08-3
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2-Fluoro-5-nitrophenol features a fluorine atom at the ortho position and a nitro group at the para position relative to the hydroxyl group, creating a strongly electron-deficient aromatic ring. This combination enhances reactivity in nucleophilic substitution and coupling reactions. The compound exhibits bench-stable handling characteristics and integrates readily into complex synthetic sequences requiring activated aryl building blocks.
2-Fluoro-5-nitrophenol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct functionalization at the phenolic hydroxyl group. Its electron-deficient aromatic ring enhances reactivity in nucleophilic substitution reactions, while the fluorine and nitro groups provide orthogonal handles for further derivatization. Bench-stable and readily purified by recrystallization, it functions efficiently in coupling protocols and heterocycle formation under standard conditions.
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GHS Pictogram :
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GHS No : GHS05,GHS09
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Signal Word : Danger
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UN#: 3077
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Class : 9
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H317-H318-H410
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Precautionary Statements : P261-P264-P270-P272-P273-P280-P302+P352-P330-P391-P501
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Lot numbers can be found on the outside label of a product: