tert-Butyl N-[(6-chloropyrimidin-4-yl)methyl]carbamate

CAS No. 1389264-32-7
Cat. No. CS-0047980
Purity≥97%
MDL No.MFCD22415185

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tert-Butyl N-[(6-chloropyrimidin-4-yl)methyl]carbamate|CS-0047980

Structure of 1389264-32-7

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Description

tert-Butyl N-[(6-chloropyrimidin-4-yl)methyl]carbamate is a bench-stable, moisture-tolerant building block featuring a chloropyrimidine core and a protected amine handle. This carbamate integrates seamlessly into medicinal chemistry campaigns, enabling direct coupling to nucleophiles or selective deprotection under mild acidic conditions. The para-chloro substitution enhances electrophilic reactivity for downstream functionalization.

Application

tert-Butyl N-[(6-chloropyrimidin-4-yl)methyl]carbamate serves as a versatile building block in medicinal chemistry, enabling the introduction of a chloropyrimidine moiety with orthogonal protection. The tert-butyl carbamate group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. It reacts efficiently in nucleophilic substitution and coupling reactions, supporting the construction of complex heterocyclic scaffolds relevant to kinase inhibitors and antiviral agents.

General Information

CAS No. 1389264-32-7
Cat. No. CS-0047980
Purity ≥97%
MDL No. MFCD22415185
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₄ClN₃O₂
Molecular Weight None
Synonym(s) 4-(Boc-aMinoMethyl)-6-chloropyriMidine
SMILES CC(C)(C)OC(=O)NCC1=NC=NC(Cl)=C1

Computational Chemistry Data

TPSA 64.11
LogP 2.1547
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 2

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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tert-Butyl N-[(6-chloropyrimidin-4-yl)methyl]carbamate

CAS No. 1389264-32-7

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