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8-Aminoquinoline-3-carboxylic acid

  • CAS No. 1416439-58-1

  • Cat. No. CS-0155673
  • Molecule weight188.18
  • Purity≥98%
  • MDL No.MFCD22690569

*For research and further manufacturing use only, not for direct human use.

8-Aminoquinoline-3-carboxylic acid|CS-0155673

Structure of 1416439-58-1

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General Information

  • CAS No. 1416439-58-1
  • Cat. No. CS-0155673
  • Purity ≥98%
  • MDL No. MFCD22690569
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₈N₂O₂
  • Molecular Weight 188.18
  • Synonym(s) None
  • SMILES C1=CC2=CC(=CN=C2C(=C1)N)C(=O)O

Description

8-Aminoquinoline-3-carboxylic acid integrates a nitrogen-rich quinoline core with strategically positioned amino and carboxylic acid groups, enabling direct conjugation in bioactive molecule design. This scaffold supports hydrogen bonding and metal coordination, enhancing binding affinity in pharmaceutical and materials applications.

Application

8-Aminoquinoline-3-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of quinoline-based scaffolds through standard coupling and functionalization reactions. Its dual amino and carboxylic acid functionalities offer orthogonal reactivity for peptide-like conjugation or derivatization, while maintaining bench stability and ease of purification. This compound functions effectively in the synthesis of kinase inhibitors, antimalarial agents, and other heterocyclic drug candidates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   76.21
  • LogP   1.5152
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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