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CS-W001157 4
Total: USD 88.00

2-Chloropyrimidine-4,5-diamine

  • CAS No. 14631-08-4

  • Cat. No. CS-W005962
  • Molecule weight144.56
  • Purity≥97%
  • MDL No.MFCD00047355

*For research and further manufacturing use only, not for direct human use.

2-Chloropyrimidine-4,5-diamine|CS-W005962

Structure of 14631-08-4

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General Information

  • CAS No. 14631-08-4
  • Cat. No. CS-W005962
  • Purity ≥97%
  • MDL No. MFCD00047355
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅ClN₄
  • Molecular Weight 144.56
  • Synonym(s) IFLAB-BB F1371-0155
  • SMILES NC1=NC(Cl)=NC=C1N

Description

2-Chloropyrimidine-4,5-diamine features a reactive chloro group flanked by two amino functionalities, enabling efficient coupling in nucleophilic substitution reactions. This electron-deficient heterocycle integrates readily into pharmaceutical scaffolds and functional materials under standard conditions.

Application

2-Chloropyrimidine-4,5-diamine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds through nucleophilic substitution. Its two diamino groups provide orthogonal reactivity for sequential functionalization, while the chloro substituent offers high electrophilicity under mild conditions. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows in API development and heterocyclic library generation.

Synthesis

  • Route1

    References

    • Journal of Organic Chemistry, , vol. 20, p. 829,833,835

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   77.82
  • LogP   0.2944
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   0

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