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Structure of 151361-87-4
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1-Ethynyl-3,5-difluorobenzene features a terminal alkyne group flanked by two fluorine atoms at the 3 and 5 positions, delivering high reactivity in copper-catalyzed coupling reactions. The electron-deficient aromatic ring enhances compatibility with palladium-mediated transformations, enabling efficient incorporation into complex molecular architectures. This bench-stable reagent combines enhanced functional group tolerance with predictable regiochemistry, streamlining access to fluorinated building blocks for medicinal chemistry and materials science applications.
1-Ethynyl-3,5-difluorobenzene serves as a versatile building block in cross-coupling chemistry, enabling efficient access to substituted arenes via palladium-catalyzed reactions. The terminal alkyne functionality facilitates Sonogashira coupling with aryl halides and pseudohalides, while the 3,5-difluoro substituents provide enhanced metabolic stability and modulate electronic properties. Bench-stable and readily purified, it functions effectively in both small-molecule synthesis and heterocycle construction for medicinal chemistry applications.
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GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Warning
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UN#: 1993
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Class : 3
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Packing Group : Ⅲ
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Hazard Statements : H226-H315-H319-H335
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P405-P501
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Lot numbers can be found on the outside label of a product: