Fmoc-D-beta-indanylglycine

CAS No. 205526-40-5
Cat. No. CS-0439309
Molecule weight413.47
Purity≥98%
MDL No.MFCD00797587

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 205526-40-5
Cat. No. CS-0439309
Purity ≥98%
MDL No. MFCD00797587
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₆H₂₃NO₄
Molecular Weight 413.47
Synonym(s) 1H-Indene-2-aceticacid, a-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2,3-dihydro-, (aR)-
SMILES OC([C@@H](C1CC2=CC=CC=C2C1)NC(OCC3C4=CC=CC=C4C5=CC=CC=C53)=O)=O

Description

Fmoc-D-beta-indanylglycine is a sterically hindered, bench-stable amino acid derivative featuring a rigid beta-indanyl moiety that enhances conformational control in peptide synthesis. The Fmoc group enables efficient N-terminal protection, while the D-configuration and indanyl side chain improve resistance to enzymatic degradation. This building block facilitates the incorporation of hydrophobic, shape-defined elements into bioactive peptides.

Application

Fmoc-D-beta-indanylglycine serves as a valuable building block in peptide synthesis, offering enhanced rigidity and metabolic stability through its D-configured beta-indanyl side chain. The Fmoc group enables efficient N-terminal protection and orthogonal deprotection, while the indanyl moiety imparts favorable conformational constraints. This compound facilitates the incorporation of sterically defined, non-natural amino acids into peptidomimetics and bioactive scaffolds, supporting applications in medicinal chemistry and macrocyclization strategies.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

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Computational Chemistry Data

TPSA 75.63
LogP 4.3933
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 5

Other Classifications

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Alanine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-D-beta-indanylglycine

CAS No. 205526-40-5

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