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Structure of 467442-21-3
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This fluorenylmethoxycarbonyl-protected amino acid derivative features a sterically hindered, electron-deficient difluorobutanoic acid backbone. Designed for efficient peptide synthesis, the Fmoc group enables orthogonal deprotection while the geminal difluoro substitution enhances metabolic stability and modulates conformational preferences in folded peptides.
(2S)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4,4-difluoro-butanoic acid serves as a valuable chiral building block for peptide synthesis, enabling the incorporation of sterically constrained, electron-deficient amino acid surrogates. The fluorenylmethoxycarbonyl (Fmoc) group provides orthogonal protection with excellent stability and ease of removal under mild basic conditions. The 4,4-difluoro substitution enhances metabolic stability and modulates backbone conformation, facilitating the construction of bioactive peptidomimetics and heterocyclic scaffolds in medicinal chemistry campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501
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Lot numbers can be found on the outside label of a product: