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CS-W001157 4
Total: USD 88.00

Diacetolol

  • CAS No. 22568-64-5

  • Cat. No. CS-0019867
  • Molecule weight308.37
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Diacetolol|CS-0019867

Structure of 22568-64-5

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General Information

  • CAS No. 22568-64-5
  • Cat. No. CS-0019867
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₄N₂O₄
  • Molecular Weight 308.37
  • Synonym(s) None
  • SMILES CC(NC1=CC=C(OCC(O)CNC(C)C)C(C(C)=O)=C1)=O

Description

A membrane-permeable phosphotyrosine phosphatase inhibitor (IC50 = 18 M). Stimulates 2-deoxyglucose transport in insulin-resistant human skeletal muscle and activates P56lck protein tyrosine kinase. Blocks TNF-dependent activation of the NF-B in human myeloid ML-1a cells. PAO inhibits the protease activities of recombinant human caspases, as well as endogenous chicken caspases that are active in extracts of preapoptotic chicken DU249 cells (S/M extracts). At 100 M, it also blocks the morphological changes of nuclear apoptosis in vitro and internucleosomal DNA fragmentation in S/M extracts without interfering with PARP or lamin A cleavage. Also known to cause complete and reversible inhibition of NADPH oxidase in human neutrophils.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   87.66
  • LogP   1.5853
  • H_Acceptors   5
  • H_Donors   3
  • Rotatable_Bonds   8

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