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CS-W001157 4
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5-Br-6-F-Desamino lenalidomide

  • CAS No. 2409005-96-3

  • Cat. No. CS-0343502
  • Purity≥95%
  • MDL No.MFCD34648177

*For research and further manufacturing use only, not for direct human use.

5-Br-6-F-Desamino lenalidomide|CS-0343502

Structure of 2409005-96-3

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General Information

  • CAS No. 2409005-96-3
  • Cat. No. CS-0343502
  • Purity ≥95%
  • MDL No. MFCD34648177
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₀BrFN₂O₃
  • Molecular Weight 341.14
  • Synonym(s) None
  • SMILES O=C1NC(=O)C(N2C(=O)C3=CC(F)=C(Br)C=C3C2)CC1

Description

This piperidine-2,6-dione derivative features a 5-bromo-6-fluoro-1-oxoisoindolin-2-yl substituent, delivering enhanced electronic modulation and metabolic stability. The fused isoindolinone core enables efficient integration into complex scaffolds, while the bromo and fluoro groups facilitate downstream functionalization via cross-coupling. This compound serves as a high-value building block in medicinal chemistry, particularly for kinase inhibitor and CNS-targeted lead development.

Application

3-(5-Bromo-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione serves as a versatile building block for the synthesis of isoindolinone-based scaffolds. Its bromo and fluoro substituents enable late-stage functionalization via palladium-catalyzed cross-coupling reactions. The diketone functionality provides a robust platform for further derivatization, including reductive amination and condensation chemistry, while maintaining bench stability and ease of purification in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   66.48
  • LogP   0.765
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   1

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