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CS-W001157 4
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Dimethyl (hydroxymethyl)phosphonate

  • CAS No. 24630-67-9

  • Cat. No. CS-W006438
  • Purity≥91%
  • MDL No.MFCD11053766

*For research and further manufacturing use only, not for direct human use.

Dimethyl (hydroxymethyl)phosphonate|CS-W006438

Structure of 24630-67-9

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General Information

  • CAS No. 24630-67-9
  • Cat. No. CS-W006438
  • Purity ≥91%
  • MDL No. MFCD11053766
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₉O₄P
  • Molecular Weight 140.08
  • Synonym(s) phosphonic acid, P-(hydroxymethyl)-, dimethyl ester
  • SMILES COP(=O)(CO)OC

Description

Dimethyl (hydroxymethyl)phosphonate features a phosphonate group tethered to a hydroxymethyl moiety, enabling direct incorporation into phosphorylated intermediates. This bench-stable reagent delivers a reactive handle for synthetic transformations in medicinal chemistry and materials science.

Application

Dimethyl (hydroxymethyl)phosphonate serves as a versatile building block in phosphorus chemistry, enabling efficient access to α-hydroxyphosphonates through nucleophilic addition and subsequent functionalization. Its hydroxymethyl group offers a handle for further derivatization, while the phosphonate moiety facilitates C–C bond formation via Horner-Wadsworth-Emmons or related olefination reactions. The compound exhibits good bench stability and compatibility with standard reaction conditions, simplifying purification and integration into synthetic sequences for medicinal chemistry and materials applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.76
  • LogP   0.4221
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   3

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