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Structure of 314771-76-1
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This quinazoline derivative features a chiral (S)-configured nitrogen substitution and a tetrahydrofuran-3-yloxy side chain, enhancing solubility and metabolic stability. The 3-chloro-4-fluorophenyl group imparts strong electron-withdrawing character, enabling precise modulation of binding affinity in kinase inhibition studies. Designed for targeted drug discovery applications.
(S)-N⁴-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine serves as a key intermediate in the synthesis of kinase inhibitors, leveraging its well-defined quinazoline core and orthogonal functional groups. The tetrahydrofuran-3-yloxy moiety provides enhanced solubility and metabolic stability, while the (S)-configured amine enables stereoselective downstream coupling reactions. This compound exhibits excellent bench stability and facilitates efficient purification, making it a practical building block for medicinal chemistry campaigns targeting ATP-competitive inhibitors.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: