4,6-Dichloro-3-nitropyridin-2-amine

CAS No. 37660-64-3
Cat. No. CS-0094679
Purity≥97%
MDL No.MFCD26383593

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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4,6-Dichloro-3-nitropyridin-2-amine|CS-0094679

Structure of 37660-64-3

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Description

4,6-Dichloro-3-nitropyridin-2-amine features a pyridine core bearing two chlorine substituents and a nitro group at the 3-position, enabling high reactivity in cross-coupling and nucleophilic substitution reactions. The electron-deficient ring facilitates efficient coupling with amines and heterocycles under mild conditions. This bench-stable compound serves as a key intermediate in the synthesis of pharmaceuticals and agrochemicals.

Application

4,6-Dichloro-3-nitropyridin-2-amine serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted pyridine scaffolds via palladium-catalyzed cross-coupling and nucleophilic substitution reactions. The dichloro pattern facilitates sequential functionalization, while the nitro and amino groups offer orthogonal reactivity for downstream transformations. Bench-stable and readily purified, it supports scalable synthesis of pharmaceutical intermediates and agrochemicals.

General Information

CAS No. 37660-64-3
Cat. No. CS-0094679
Purity ≥97%
MDL No. MFCD26383593
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₃Cl₂N₃O₂
Molecular Weight 208.00
Synonym(s) 4,6-Dichloro-3-nitro-2-pyridinamine
SMILES NC1=NC(Cl)=CC(Cl)=C1[N+]([O-])=O

Computational Chemistry Data

TPSA 82.05
LogP 1.8788
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Nitro compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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4,6-Dichloro-3-nitropyridin-2-amine

CAS No. 37660-64-3

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