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CS-W001157 4
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3-Amino-2,2-difluoropropanoic acid

  • CAS No. 428452-49-7

  • Cat. No. CS-0089610
  • Molecule weight125.07
  • Purity≥95%
  • MDL No.MFCD05864327

*For research and further manufacturing use only, not for direct human use.

3-Amino-2,2-difluoropropanoic acid|CS-0089610

Structure of 428452-49-7

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General Information

  • CAS No. 428452-49-7
  • Cat. No. CS-0089610
  • Purity ≥95%
  • MDL No. MFCD05864327
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₅F₂NO₂
  • Molecular Weight 125.07
  • Synonym(s) 3-AMINO-2,2-DIFLUORO-PROPIONIC ACID
  • SMILES O=C(O)C(F)(F)CN

Description

3-Amino-2,2-difluoropropanoic acid features a trifluoromethyl-like electronic profile with enhanced stability due to the geminal difluoro substitution. This bench-stable amino acid analog integrates readily into peptide synthesis workflows, offering improved metabolic resistance and controlled polarity for applications in medicinal chemistry and probe development.

Application

3-Amino-2,2-difluoropropanoic acid serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated amino acid derivatives with enhanced metabolic stability. Its difluoromethyl group imparts favorable lipophilicity and resistance to oxidative metabolism, while the α-amino and carboxylic acid functionalities support straightforward peptide coupling and derivatization. The compound exhibits good bench stability and is amenable to standard purification methods, facilitating integration into multi-step synthetic sequences for targeted bioactive molecule development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   63.32
  • LogP   -0.335
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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