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Structure of 1145-93-3
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Diethyl (4-methoxybenzyl)phosphonate features a methoxy-substituted benzyl group that enhances solubility and electronic modulation. The phosphonate moiety enables direct functionalization in Horner-Wadsworth-Emmons reactions, delivering high stereoselectivity. This bench-stable reagent integrates seamlessly into synthetic sequences requiring controlled C–C bond formation under mild conditions.
Diethyl (4-methoxybenzyl)phosphonate serves as a versatile synthon for the stereoselective construction of α-aminophosphonates and phosphonate-containing heterocycles. Its benzylic phosphonate functionality exhibits excellent stability under standard reaction conditions, enabling efficient alkylations and coupling reactions with broad functional group tolerance. The 4-methoxybenzyl group facilitates convenient purification via chromatography and can be selectively cleaved under mild acidic conditions, making it ideal for late-stage functionalization in medicinal chemistry and natural product synthesis.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: