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CS-W001157 4
Total: USD 88.00

3-Methoxy-4-pyridinamine

  • CAS No. 52334-90-4

  • Cat. No. CS-W007049
  • Molecule weightNone
  • Purity≥96%
  • MDL No.MFCD09991938

*For research and further manufacturing use only, not for direct human use.

3-Methoxy-4-pyridinamine|CS-W007049

Structure of 52334-90-4

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General Information

  • CAS No. 52334-90-4
  • Cat. No. CS-W007049
  • Purity ≥96%
  • MDL No. MFCD09991938
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O
  • Molecular Weight None
  • Synonym(s) 4-pyridinamine, 3-methoxy-
  • SMILES NC1=C(OC)C=NC=C1

Description

3-Methoxy-4-pyridinamine features a pyridine core functionalized with a methoxy group at the 3-position and an amino group at the 4-position, delivering enhanced solubility and electron-donating character. This dual functionality enables efficient integration into pharmaceutical intermediates and ligand design, particularly in transition metal catalysis where nitrogen coordination is critical. The molecule exhibits bench-stable handling under standard conditions.

Application

3-Methoxy-4-pyridinamine serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds via standard coupling reactions. Its pyridine core provides moderate basicity and enhanced solubility, while the ortho-methoxy and amino groups offer complementary sites for derivatization. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
    • null|null
      19355-04-5
    • ~97%
    • In-stock
      3-Methoxy-4-pyridinamine|CS-W007049
      52334-90-4

    References

    • Wu, Zong-Quan; Jiang, Xi-Kui; Li, Zhan-Ting Tetrahedron Letters, 2005 , vol. 46, # 46 p. 8067 - 8070
  • Route2
    • null|null
      1336-21-6
    • null|null
      19355-04-5
    • null|null
      75-09-2
    • ~63%
    • In-stock
      3-Methoxy-4-pyridinamine|CS-W007049
      52334-90-4

    References

    • C.D. Searle and Co. Patent: US5652363 A1, 1997 ;
  • Route3
    • null|null
      14906-61-7
    • ~%
    • In-stock
      3-Methoxy-4-pyridinamine|CS-W007049
      52334-90-4

    References

    • den Hertog; van Ammers Recueil des Travaux Chimiques des Pays-Bas, 1955 , vol. 74, p. 1160,1164

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P304+P341-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P363-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   0.6724
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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