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Structure of 54237-53-5
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6-Bromopyrazin-2-amine features a bromine substituent at the 6-position and an amino group at the 2-position of the pyrazine ring, enabling diverse cross-coupling transformations. This electron-deficient heterocycle integrates readily into pharmaceutical scaffolds and functional materials, offering high reactivity in palladium-catalyzed processes under standard conditions.
6-Bromopyrazin-2-amine serves as a versatile building block in medicinal chemistry, enabling direct functionalization via palladium-catalyzed cross-coupling reactions. Its bromine substituent facilitates efficient C–C and C–N bond formation under standard Suzuki, Stille, or Buchwald-Hartwig conditions. The pyrazine core provides excellent planarity and nitrogen-rich heterocyclic character, enhancing binding affinity in kinase inhibitors and other bioactive scaffolds. Bench-stable and readily purified by recrystallization, it functions as a reliable intermediate for API development and target-oriented synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: