4-Chloro-1-methylpiperidine

CAS No. 5570-77-4
Cat. No. CS-W013387
Purity≥97%
MDL No.MFCD00044489

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

4-Chloro-1-methylpiperidine is a sterically hindered, bench-stable piperidine derivative featuring a chlorine atom at the 4-position and a methyl group on nitrogen. This combination imparts enhanced metabolic stability and favorable lipophilicity, making it a valuable scaffold in medicinal chemistry for optimizing pharmacokinetic profiles.

Application

4-Chloro-1-methylpiperidine serves as a versatile building block in medicinal chemistry, enabling the construction of diverse heterocyclic scaffolds through nucleophilic substitution and coupling reactions. Its chloro group at the 4-position provides high reactivity for C–N bond formation, while the N-methyl functionality enhances lipophilicity and metabolic stability. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols, facilitating efficient functionalization in API development workflows.

General Information

CAS No. 5570-77-4
Cat. No. CS-W013387
Purity ≥97%
MDL No. MFCD00044489
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₂ClN
Molecular Weight 133.62
Synonym(s) Piperidine, 4-chloro-1-methyl-; 4-Chloro-1-methylpiperidine
SMILES CN1CCC(CC1)Cl

Computational Chemistry Data

TPSA 3.24
LogP 1.3194
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS02,GHS05
Signal Word : Danger	UN#: 2924
Class : 3 (8)	Packing Group : Ⅲ
Hazard Statements : H226-H314-H412
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P264-P273-P280-P301+P330+P331-P304+P340-P363-P370+P378-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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4-Chloro-1-methylpiperidine

CAS No. 5570-77-4

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