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CS-W001157 4
Total: USD 88.00

4-Ethoxyaniline hydrochloride

  • CAS No. 637-56-9

  • Cat. No. CS-0187001
  • Molecule weight173.64
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Ethoxyaniline hydrochloride|CS-0187001

Structure of 637-56-9

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General Information

  • CAS No. 637-56-9
  • Cat. No. CS-0187001
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₂ClNO
  • Molecular Weight 173.64
  • Synonym(s) p-phenetidinium chloride
  • SMILES CCOC1=CC=C(C=C1)N.Cl

Description

4-Ethoxyaniline hydrochloride features a para-ethoxy-substituted aniline core, delivering enhanced solubility and stability in aqueous and polar organic media. This bench-stable salt form facilitates handling and integration into synthetic workflows involving amine coupling or electrophilic substitution reactions.

Application

4-Ethoxyaniline hydrochloride serves as a stable, bench-ready building block for pharmaceutical and agrochemical synthesis. Its aniline functionality enables direct coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig protocols, while the ethoxy group provides moderate electron-donating character to modulate reactivity. The hydrochloride salt enhances solubility and handling, facilitating purification and integration into multi-step synthetic sequences.

Synthesis

  • Route1

    References

    • Wang, Gong-Bao; Wang, Lin-Fa; Li, Chao-Zhang; Sun, Jing; Zhou, Guang-Ming; Yang, Da-Cheng Research on Chemical Intermediates, 2012 , vol. 38, # 1 p. 77 - 89
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 27, # 3 p. 347 - 357
  • Route3
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      156-43-4
    • ~%
    • In-stock
      4-Ethoxyaniline hydrochloride|CS-0187001
      637-56-9

    References

    • Research on Chemical Intermediates, , vol. 38, # 1 p. 77 - 89

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   2.0893
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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