6-Chlorobenzo[b]thiophene

CAS No. 66490-20-8
Cat. No. CS-0119377
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 66490-20-8

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Description

6-Chlorobenzo[b]thiophene serves as a critical heterocyclic scaffold in medicinal chemistry and materials science. This electron-deficient aromatic system integrates readily into pharmaceutical intermediates and functional polymers. Its chlorine substituent enables direct cross-coupling reactions, while the fused thiophene ring enhances planarity and π-conjugation. Bench-stable and moisture-tolerant, it facilitates efficient synthesis under standard conditions.

Application

6-Chlorobenzo[b]thiophene serves as a versatile heterocyclic building block in medicinal chemistry and materials science, enabling efficient transition-metal-catalyzed couplings due to its well-defined reactivity at the chlorine site. The scaffold exhibits excellent bench stability, facilitates straightforward purification, and functions effectively in cross-coupling reactions with broad functional group tolerance. Its planar, electron-deficient structure supports integration into advanced API scaffolds and conjugated systems.

General Information

CAS No. 66490-20-8
Cat. No. CS-0119377
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₅ClS
Molecular Weight 168.64
Synonym(s) 6-Chlorobenzothiophene
SMILES ClC1=CC=C(C=CS2)C2=C1

Computational Chemistry Data

TPSA 0
LogP 3.5547
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H332-H335
Precautionary Statements : P233-P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P340-P362-P403-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Benzothiophene compounds

Key Words

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6-Chlorobenzo[b]thiophene

CAS No. 66490-20-8

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