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Structure of 67169-22-6
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2-Methyl-4-(trifluoromethyl)aniline features a trifluoromethyl group that imparts enhanced electron-withdrawal and metabolic stability, while the methyl substituent provides steric modulation. This combination enhances solubility in organic solvents and facilitates selective coupling reactions under mild conditions. The compound serves as a key building block in agrochemicals and pharmaceutical intermediates.
2-Methyl-4-(trifluoromethyl)aniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling the construction of bioactive heterocycles via electrophilic substitution and coupling reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the ortho-methyl substituent provides steric and electronic modulation. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for multi-step synthetic sequences and scale-up applications.
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2810
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H302+H312-H315-H319-H331-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: