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CS-W001157 4
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Boc-NH-PEG4-CH2CH2NH2

  • CAS No. 811442-84-9

  • Cat. No. CS-W008352
  • Purity≥97%
  • MDL No.MFCD16619339

*For research and further manufacturing use only, not for direct human use.

Boc-NH-PEG4-CH2CH2NH2|CS-W008352

Structure of 811442-84-9

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General Information

  • CAS No. 811442-84-9
  • Cat. No. CS-W008352
  • Purity ≥97%
  • MDL No. MFCD16619339
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₃₂N₂O₆
  • Molecular Weight 336.42
  • Synonym(s) Boc-NH-PEG4-amine
  • SMILES O=C(OC(C)(C)C)NCCOCCOCCOCCOCCN

Description

Boc-NH-PEG4-CH2CH2NH2 features a tert-butoxycarbonyl-protected amine terminus linked to a four-ethylene glycol spacer, delivering a hydrophilic, stable platform for conjugation. The terminal primary amine enables straightforward functionalization under mild conditions, while the PEG4 chain enhances solubility and reduces aggregation. This structure supports modular synthesis in peptide modification, bioconjugation, and targeted delivery applications.

Application

Boc-NH-PEG4-CH2CH2NH2 serves as a versatile bifunctional linker for conjugation and solid-phase synthesis. The Boc-protected amine enables selective coupling under mild conditions, while the distal primary amine facilitates attachment to biomolecules or surfaces. The PEG4 spacer provides enhanced solubility and reduced steric hindrance, improving accessibility in bioconjugation workflows. Bench-stable and compatible with standard purification methods, it functions effectively in peptide modification, antibody-drug conjugate development, and functionalized nanoparticle synthesis.

Synthesis

  • Route1

    References

    • Ishida, Manabu; Watanabe, Hideaki; Takigawa, Kazumasa; Kurishita, Yasutaka; Oki, Choji; Nakamura, Akinobu; Hamachi, Itaru; Tsukiji, Shinya Journal of the American Chemical Society, 2013 , vol. 135, # 34 p. 12684 - 12689

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   101.27
  • LogP   0.5362
  • H_Acceptors   7
  • H_Donors   2
  • Rotatable_Bonds   14

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