(R)-1-(4-Chloro-2-fluorophenyl)ethan-1-amine hydrochloride

CAS No. 856562-91-9
Cat. No. CS-0197455
Molecule weight210.08
Purity≥95%
MDL No.None

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(R)-1-(4-Chloro-2-fluorophenyl)ethan-1-amine hydrochloride|CS-0197455

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General Information

CAS No. 856562-91-9
Cat. No. CS-0197455
Purity ≥95%
MDL No. None
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₁₀Cl₂FN
Molecular Weight 210.08
Synonym(s) Benzenemethanamine, 4-chloro-2-fluoro-a-methyl-, (aR)- HYDROCHLORIDE
SMILES [C@H](C)(N)C1=C(F)C=C(Cl)C=C1.Cl

Description

(R)-1-(4-Chloro-2-fluorophenyl)ethan-1-amine hydrochloride is a chiral amine featuring a fluorinated aromatic ring and a stereogenic center. This bench-stable, moisture-tolerant compound integrates readily into asymmetric synthesis workflows. Its electron-deficient phenyl moiety facilitates directed functionalization, enabling efficient access to bioactive intermediates in medicinal chemistry.

Application

(R)-1-(4-Chloro-2-fluorophenyl)ethan-1-amine hydrochloride serves as a chiral building block for pharmaceutical intermediates, enabling stereoselective synthesis of bioactive molecules. Its bench-stable hydrochloride salt facilitates handling and purification, while the aryl amine functionality supports diverse transformations including Suzuki-Miyaura coupling, amide formation, and heterocycle construction. The ortho-fluoro-chloro substitution pattern enhances reactivity in directed metalation and enables downstream functionalization in medicinal chemistry workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 26.02
LogP 2.9206
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-1-(4-Chloro-2-fluorophenyl)ethan-1-amine hydrochloride

CAS No. 856562-91-9

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