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Structure of 454-82-0
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2-Amino-5-(trifluoromethyl)phenol features a strategically positioned trifluoromethyl group that enhances electron-withdrawing character and metabolic stability. This phenolic scaffold integrates a primary amine for conjugation, enabling direct use in bioconjugation and medicinal chemistry applications. The compound exhibits robust bench stability and solubility in common organic solvents, facilitating straightforward handling in synthetic workflows.
2-Amino-5-(trifluoromethyl)phenol serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and functionalized aromatic scaffolds. Its dual amino and phenolic functionalities offer orthogonal reactivity for sequential derivatization, while the electron-withdrawing trifluoromethyl group enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for use in iterative synthetic campaigns targeting pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: