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Structure of 99368-68-0
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6-Chloro-5-(trifluoromethyl)pyridin-3-amine features a trifluoromethyl group that enhances metabolic stability and lipophilicity, while the chloro substituent enables selective cross-coupling reactions. This electron-deficient pyridine scaffold integrates readily into bioactive molecules, serving as a key building block in medicinal chemistry for kinase inhibitors and agrochemicals.
6-Chloro-5-(trifluoromethyl)pyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via palladium-catalyzed cross-coupling reactions. The chloro group facilitates reliable C–C and C–N bond formation under standard conditions, while the trifluoromethyl moiety enhances metabolic stability and lipophilicity. Its bench-stable nature and compatibility with diverse functional groups make it ideal for iterative synthesis in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: