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Structure of 446-65-1
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2,2,2-Trifluoro-1-(p-tolyl)ethanol features a trifluoromethyl group adjacent to a benzylic alcohol, delivering enhanced stability and polarity. The para-tolyl substituent imparts favorable solubility and steric profile, enabling efficient incorporation into chiral syntheses. This bench-stable compound serves as a key building block in asymmetric catalysis and pharmaceutical intermediates.
2,2,2-Trifluoro-1-(p-tolyl)ethanol serves as a stable, bench-friendly building block for fluorinated aromatic systems. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the benzylic alcohol enables straightforward derivatization via oxidation, protection, or coupling reactions. This compound functions effectively in the synthesis of bioactive molecules and fluorinated pharmaceutical intermediates, offering predictable reactivity and excellent functional group tolerance in standard organic transformations.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: