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CS-W001157 4
Total: USD 88.00

2-Methylthiazole-5-carbaldehyde

  • CAS No. 1003-60-7

  • Cat. No. CS-W019857
  • Purity≥96%
  • MDL No.MFCD09864617

*For research and further manufacturing use only, not for direct human use.

2-Methylthiazole-5-carbaldehyde|CS-W019857

Structure of 1003-60-7

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General Information

  • CAS No. 1003-60-7
  • Cat. No. CS-W019857
  • Purity ≥96%
  • MDL No. MFCD09864617
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅NOS
  • Molecular Weight 127.16
  • Synonym(s) 2-Methyl-1,3-thiazole-5-carbaldehyde
  • SMILES O=CC1=CN=C(C)S1

Description

2-Methylthiazole-5-carbaldehyde features a reactive aldehyde group flanked by a methyl-substituted thiazole ring, enabling direct incorporation into heterocyclic scaffolds. This electron-deficient system facilitates nucleophilic addition and condensation reactions under mild conditions, offering efficient access to functionalized thiazole derivatives for medicinal chemistry applications.

Application

2-Methylthiazole-5-carbaldehyde serves as a versatile heterocyclic building block in medicinal chemistry and synthetic organic applications. Its aldehyde functionality enables direct incorporation into Ugi, Mannich, and reductive amination reactions, while the thiazole core provides metabolic stability and π-stacking potential. The methyl group enhances solubility and facilitates downstream functionalization via oxidation or halogenation. Bench-stable and readily purified by column chromatography, it functions reliably in multi-step synthesis of kinase inhibitors and bioactive scaffolds.

Synthesis

  • Route1
    • null|null
      2065-75-0
    • In-stock
      Thioacetamide|CS-W018499
      62-55-5
    • ~28%
    • In-stock
      2-Methylthiazole-5-carbaldehyde|CS-W019857
      1003-60-7

    References

    • Khanna; Yu; Huff; Weier; Xu; Koszyk; Collins; Cogburn; Isakson; Koboldt; Masferrer; Perkins; Seibert; Veenhuizen; Yuan; Yang; Zhang Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3168 - 3185
  • Route2

    References

    • EP1186604 A1, ; Page 110 ; EP 1186604 A1
  • Route3

    References

    • EP1186604 A1, ; EP 1186604 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.26402
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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