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Structure of 1003-60-7
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2-Methylthiazole-5-carbaldehyde features a reactive aldehyde group flanked by a methyl-substituted thiazole ring, enabling direct incorporation into heterocyclic scaffolds. This electron-deficient system facilitates nucleophilic addition and condensation reactions under mild conditions, offering efficient access to functionalized thiazole derivatives for medicinal chemistry applications.
2-Methylthiazole-5-carbaldehyde serves as a versatile heterocyclic building block in medicinal chemistry and synthetic organic applications. Its aldehyde functionality enables direct incorporation into Ugi, Mannich, and reductive amination reactions, while the thiazole core provides metabolic stability and π-stacking potential. The methyl group enhances solubility and facilitates downstream functionalization via oxidation or halogenation. Bench-stable and readily purified by column chromatography, it functions reliably in multi-step synthesis of kinase inhibitors and bioactive scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: