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Structure of 1003865-65-3
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4-(Difluoromethoxy)-2-fluoroaniline features a strategically positioned difluoromethoxy group and ortho-fluoro substituent, enhancing electron deficiency and metabolic stability. This combination enables direct incorporation into bioactive scaffolds, particularly in agrochemicals and pharmaceutical intermediates, where improved membrane permeability and resistance to oxidative degradation are critical.
4-(Difluoromethoxy)-2-fluoroaniline serves as a valuable fluorinated aromatic building block for medicinal chemistry and agrochemical synthesis. Its ortho-fluoro and difluoromethoxy substituents enable enhanced metabolic stability and modulated lipophilicity. The compound exhibits bench stability, tolerates a range of functional groups, and participates reliably in Suzuki-Miyaura, Buchwald-Hartwig, and other standard coupling reactions, facilitating efficient construction of complex heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: