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CS-W001157 4
Total: USD 88.00

4-(4-Hydroxyphenyl)benzaldehyde

  • CAS No. 100980-82-3

  • Cat. No. CS-0147257
  • Molecule weightNone
  • Purity≥96%
  • MDL No.MFCD00804656

*For research and further manufacturing use only, not for direct human use.

4-(4-Hydroxyphenyl)benzaldehyde|CS-0147257

Structure of 100980-82-3

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General Information

  • CAS No. 100980-82-3
  • Cat. No. CS-0147257
  • Purity ≥96%
  • MDL No. MFCD00804656
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₀O₂
  • Molecular Weight None
  • Synonym(s) 4-Hydroxy-biphenyl-4'-carboxyaldehyde
  • SMILES OC1=CC=C(C2=CC=C(C=O)C=C2)C=C1

Description

4-(4-Hydroxyphenyl)benzaldehyde features a conjugated diaryl scaffold with complementary phenolic and aldehyde functionalities. This bifunctional architecture enables direct incorporation into Suzuki-Miyaura couplings and oxidative transformations, serving as a key intermediate in the synthesis of bioactive stilbene analogs and advanced fluorescent probes.

Application

4-(4-Hydroxyphenyl)benzaldehyde serves as a versatile building block in medicinal chemistry and materials science, enabling efficient synthesis of biaryl scaffolds and functionalized heterocycles. Its dual functionality—phenolic hydroxyl and aldehyde groups—facilitates selective derivatization, including oxidation, condensation, and Suzuki coupling reactions. The compound exhibits excellent bench stability and is readily purified by recrystallization, making it well-suited for high-throughput screening campaigns and scalable synthesis workflows.

Synthesis

  • Route1
    • null|null
      716344-19-3
    • ~99%
    • In-stock
      4-(4-Hydroxyphenyl)benzaldehyde|CS-0147257
      100980-82-3

    References

    • WO2004/99122 A2, ; Page 15; 21 ; WO 2004/099122 A2
  • Route2

    References

    • Organic Letters, , vol. 4, # 18 p. 3071 - 3073
  • Route3

    References

    • Bioorganic and Medicinal Chemistry, , vol. 12, # 10 p. 2553 - 2570

Safety Information

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GHS Pictogram : N/A
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UN#: N/A
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Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.8717
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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