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CS-W001157 4
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5-Formylbenzothiophene

  • CAS No. 10133-30-9

  • Cat. No. CS-0034908
  • Molecule weight162.21
  • Purity≥98%
  • MDL No.MFCD05663673

*For research and further manufacturing use only, not for direct human use.

5-Formylbenzothiophene|CS-0034908

Structure of 10133-30-9

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General Information

  • CAS No. 10133-30-9
  • Cat. No. CS-0034908
  • Purity ≥98%
  • MDL No. MFCD05663673
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆OS
  • Molecular Weight 162.21
  • Synonym(s) 1-Benzothiophene-5-carbaldehyde
  • SMILES O=CC1=CC=C2C(C=CS2)=C1

Application

5-Formylbenzothiophene serves as a versatile building block in medicinal chemistry and materials science, enabling direct functionalization at the benzothiophene core. The aldehyde group facilitates nucleophilic additions, reductive amination, and condensation reactions, while the thiophene ring provides electronic stability and π-conjugation. Its bench-stable nature and compatibility with common protecting group strategies make it ideal for multi-step synthesis of heterocyclic scaffolds and API intermediates.

Synthesis

  • Route1

    References

    • WO2007/53131 A2, ; Page/Page column 176-177 ; WO 2007/053131 A2
  • Route2
    • In-stock
      5-Methylbenzo[b]thiophene|CS-0095170
      14315-14-1
    • null|null
      94-36-0
    • ~48%
    • In-stock
      5-Formylbenzothiophene|CS-0034908
      10133-30-9

    References

    • US4668697 A1, ;
  • Route3
    • null|null
      97231-81-7
    • ~73%
    • In-stock
      5-Formylbenzothiophene|CS-0034908
      10133-30-9

    References

    • Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 603 - 607

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.7138
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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