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Structure of 101861-63-6
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4,6-Dichloroindole-2-carboxylic acid features a rigid indole core with two chlorine atoms at the 4 and 6 positions, enhancing electron-withdrawal and metabolic stability. The carboxylic acid group enables direct coupling or derivatization in synthetic routes. This compound serves as a key building block for bioactive heterocycles, particularly in medicinal chemistry applications where halogenated scaffolds improve target binding affinity and pharmacokinetic properties.
4,6-Dichloroindole-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of indole-based heterocycles through standard coupling and functionalization protocols. Its dual chloro substituents enhance electrophilicity at C4 and C6, facilitating palladium-catalyzed cross-couplings and nucleophilic aromatic substitution reactions. The carboxylic acid group provides a handle for amide formation, esterification, or salt generation, supporting purification and derivatization. Bench-stable and readily handled, it functions effectively in multi-step syntheses targeting API scaffolds and kinase inhibitors.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: