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CS-W001157 4
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Chlorodi-p-tolylphosphane

  • CAS No. 1019-71-2

  • Cat. No. CS-0182673
  • Purity≥97%
  • MDL No.MFCD01630844

*For research and further manufacturing use only, not for direct human use.

Chlorodi-p-tolylphosphane|CS-0182673

Structure of 1019-71-2

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General Information

  • CAS No. 1019-71-2
  • Cat. No. CS-0182673
  • Purity ≥97%
  • MDL No. MFCD01630844
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₄ClP
  • Molecular Weight None
  • Synonym(s) Bis(4-methylphenyl)chlorophosphine
  • SMILES ClP(C1=CC=C(C)C=C1)C2=CC=C(C)C=C2

Description

Biotinylation reagent incorporating a spacer with a cleavable disulfide linkage. Typically coupled to primary amine in the pH range 6.5-8.5. Cleavage of disulfide requires reducing agent allowing mild recovery of biotinylated compound.

Synthesis

  • Route1

    References

    • Narsireddy, Meda; Yamamoto, Yoshinori Journal of Organic Chemistry, 2008 , vol. 73, # 24 p. 9698 - 9709
  • Route2
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      683-85-2
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      696-61-7
    • ~%
    • Chlorodi-p-tolylphosphane|CS-0182673
      1019-71-2

    References

    • Journal of the American Chemical Society, , vol. 129, # 25 p. 7734 - 7735
  • Route3
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      106-38-7
    • ~%
    • Chlorodi-p-tolylphosphane|CS-0182673
      1019-71-2

    References

    • Journal of the American Chemical Society, , vol. 100, p. 7304 - 7311

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   3.88994
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   2

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