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CS-W001157 4
Total: USD 88.00

4-Methoxypyridin-2-amine

  • CAS No. 10201-73-7

  • Cat. No. CS-D1774
  • Purity≥97%
  • MDL No.MFCD07437849

*For research and further manufacturing use only, not for direct human use.

4-Methoxypyridin-2-amine|CS-D1774

Structure of 10201-73-7

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General Information

  • CAS No. 10201-73-7
  • Cat. No. CS-D1774
  • Purity ≥97%
  • MDL No. MFCD07437849
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O
  • Molecular Weight 124.14
  • Synonym(s) None
  • SMILES NC1=NC=CC(OC)=C1

Description

4-Methoxypyridin-2-amine features a pyridine ring bearing a methoxy group at the 4-position and an amino substituent at the 2-position, delivering enhanced solubility and stability. This electron-rich scaffold integrates readily into pharmaceutical intermediates, enabling efficient coupling reactions under mild conditions.

Application

4-Methoxypyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of pyridine-based scaffolds through standard coupling and functionalization reactions. Its ortho-amino and methoxy groups provide complementary reactivity for palladium-catalyzed cross-couplings and electrophilic substitutions, while offering good bench stability and ease of purification. This compound functions effectively in the synthesis of kinase inhibitors and other bioactive heterocycles.

Synthesis

  • Route1
    • In-stock
      2-Amino-4-chloropyridine|CS-W008962
      19798-80-2
    • null|null
      124-41-4
    • ~56%
    • In-stock
      4-Methoxypyridin-2-amine|CS-D1774
      10201-73-7

    References

    • Journal of Organometallic Chemistry, , vol. 523, # 2 p. 145 - 151
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 54, # 8 p. 3076 - 3080
  • Route3

    References

    • Advanced Synthesis and Catalysis, , vol. 355, # 4 p. 627 - 631

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   0.6724
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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