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Structure of 1021535-48-7
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2-(1,1-Difluoroethyl)-4-pyridinecarboxylic acid features a sterically hindered difluoroethyl group attached to the pyridine ring, enhancing metabolic stability and lipophilicity. This electron-deficient heterocycle integrates readily into medicinal chemistry scaffolds, enabling efficient access to bioactive compounds with improved membrane permeability and target engagement.
2-(1,1-Difluoroethyl)-4-pyridinecarboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of fluorinated heterocyclic scaffolds. The difluoroethyl group imparts enhanced metabolic stability and lipophilicity, while the pyridinecarboxylic acid moiety facilitates coupling reactions and hydrogen bonding interactions. This compound exhibits good bench stability and is compatible with standard functional group transformations, making it well-suited for parallel synthesis and lead optimization campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: