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Structure of 10406-05-0
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5-Chloro-1H-indole-3-carboxylic acid features a chlorinated indole core with a carboxylic acid group at the 3-position, enabling direct conjugation in synthetic transformations. This electron-deficient scaffold integrates readily into bioactive molecule frameworks, offering enhanced metabolic stability and tunable polarity for medicinal chemistry applications.
5-Chloro-1H-indole-3-carboxylic acid serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling direct incorporation into indole-based scaffolds. Its carboxylic acid functionality facilitates amide coupling, esterification, and salt formation under standard conditions. The 5-chloro substituent provides a handle for further functionalization via palladium-catalyzed cross-coupling reactions. Bench-stable and readily purified by recrystallization, it functions effectively in both small-molecule discovery and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: