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CS-W001157 4
Total: USD 88.00

(5-Methylthiophen-2-yl)methanamine

  • CAS No. 104163-34-0

  • Cat. No. CS-0035951
  • Molecule weightNone
  • Purity≥98%
  • MDL No.MFCD00965306

*For research and further manufacturing use only, not for direct human use.

(5-Methylthiophen-2-yl)methanamine|CS-0035951

Structure of 104163-34-0

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General Information

  • CAS No. 104163-34-0
  • Cat. No. CS-0035951
  • Purity ≥98%
  • MDL No. MFCD00965306
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉NS
  • Molecular Weight None
  • Synonym(s) 5-methylthiophen-2-yl-methylamine
  • SMILES CC1=CC=C(CN)S1

Description

(5-Methylthiophen-2-yl)methanamine features a thiophene core with methyl and methyleneamine substituents positioned for orthogonal reactivity. This bench-stable, moisture-tolerant scaffold integrates readily into bioactive molecule design, offering a polar handle for conjugation while maintaining aromatic stability.

Application

(5-Methylthiophen-2-yl)methanamine serves as a versatile building block in medicinal chemistry, enabling the synthesis of thiophene-based pharmaceutical intermediates. Its benzylic amine functionality exhibits good bench stability and compatibility with standard functional group transformations. The molecule functions effectively in coupling reactions, facilitates heterocycle elaboration, and supports the construction of bioactive scaffolds through straightforward derivatization pathways.

Synthesis

  • Route1
    • (E)-5-methylthiophene-2-carbaldehyde oxime|CS-0465506
      42456-40-6
    • ~%
    • In-stock
      (5-Methylthiophen-2-yl)methanamine|CS-0035951
      104163-34-0

    References

    • WO2004/72070 A1, ; Page 48-49 ; WO 2004/072070 A1
  • Route2

    References

    • US5939398 A1, ;
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 70, p. 4018 Journal of the American Chemical Society, , vol. 70, p. 1146,4013

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.51522
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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