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CS-W001157 4
Total: USD 88.00

(R)-1-(o-Tolyl)ethan-1-amine

  • CAS No. 105615-45-0

  • Cat. No. CS-0000275
  • Purity≥97%
  • MDL No.MFCD06761816

*For research and further manufacturing use only, not for direct human use.

(R)-1-(o-Tolyl)ethan-1-amine|CS-0000275

Structure of 105615-45-0

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General Information

  • CAS No. 105615-45-0
  • Cat. No. CS-0000275
  • Purity ≥97%
  • MDL No. MFCD06761816
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₃N
  • Molecular Weight 135.21
  • Synonym(s) (R)-o-Methyl-a-phenethylamine
  • SMILES N[C@H](C)C1=CC=CC=C1C

Description

(R)-1-(o-Tolyl)ethan-1-amine is a chiral amine featuring a benzyl scaffold with an ortho-methyl substituent, offering enhanced steric and electronic control in asymmetric synthesis. This bench-stable, moisture-tolerant amine integrates readily into catalytic systems for enantioselective transformations, enabling efficient access to optically active intermediates in pharmaceutical development.

Application

(R)-1-(o-Tolyl)ethan-1-amine serves as a chiral building block for asymmetric synthesis, offering high enantiomeric purity and bench stability. Its ortho-tolyl group provides steric and electronic modulation, enhancing selectivity in transition-metal-catalyzed couplings and enabling efficient access to bioactive amine scaffolds. Functions effectively in reductive amination and Mannich reactions, with straightforward purification via crystallization or distillation.

Synthesis

  • Route1
    • In-stock
      1-(2-Methylphenyl)ethanamine|CS-0213133
      42142-17-6
    • ~0%
    • (S)-1-(o-tolyl)Ethan-1-amine|CS-0000280
      76279-30-6
    • In-stock
      (R)-1-(o-Tolyl)ethan-1-amine|CS-0000275
      105615-45-0

    References

    • Balint, Jozsef; Schindler, Jozsef; Egri, Gabriella; Hanusz, Miklos; Marthi, Katalin; Juvancz, Zoltan; Fogassy, Elemer Tetrahedron Asymmetry, 2004 , vol. 15, # 21 p. 3401 - 3405
  • Route2

    References

    • Liebigs Annalen der Chemie, , # 8 p. 795 - 805
  • Route3
    • null|null
      128113-70-2
    • ~%
    • (S)-1-(o-tolyl)Ethan-1-amine|CS-0000280
      76279-30-6
    • In-stock
      (R)-1-(o-Tolyl)ethan-1-amine|CS-0000275
      105615-45-0

    References

    • Liebigs Annalen der Chemie, , # 8 p. 795 - 805

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.01472
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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