2-Amino-5-(2-hydroxyethyl)thiazole

Name: 2-Amino-5-(2-hydroxyethyl)thiazole
Brand: ChemScene
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CAS No. 105773-93-1
Cat. No. CS-0158324
Molecule weight144.19
Purity≥97%
MDL No.MFCD13184156

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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2-Amino-5-(2-hydroxyethyl)thiazole|CS-0158324

Structure of 105773-93-1

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General Information

CAS No. 105773-93-1
Cat. No. CS-0158324
Purity ≥97%
MDL No. MFCD13184156
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₈N₂OS
Molecular Weight 144.19
Synonym(s) 2-(2-aMinothiazol-5-yl)ethanol
SMILES OCCC1=CN=C(N)S1

Description

2-Amino-5-(2-hydroxyethyl)thiazole features a polar hydroxymethyl side chain that enhances solubility in aqueous and protic solvents, enabling efficient integration into bioconjugation workflows. The amino group serves as a reactive handle for coupling reactions, while the thiazole core provides metabolic stability and structural rigidity. This compound functions as a key building block in medicinal chemistry and fluorescent probe development.

Application

2-Amino-5-(2-hydroxyethyl)thiazole serves as a versatile building block for thiazole-based heterocycles, enabling efficient access to medicinally relevant scaffolds. The amino and hydroxyethyl functionalities provide orthogonal handles for derivatization via amide coupling, alkylation, or oxidation reactions. Bench-stable and readily purified by recrystallization, it functions effectively in standard synthetic workflows for API intermediates and kinase inhibitor precursors.

Synthesis

Route1
- 1191-99-7
- 17356-08-0
- ~59%
- In-stock
  
  105773-93-1
References
- MANNKIND CORPORATION; TOLERO PHARMACEUTICALS, INC.; ZENG, Qingping; FARIS, Mary; MOLLARD, Alexis; WARNER, Steven L.; FLYNN, Gary A. Patent: WO2014/52365 A1, 2014 ; Location in patent: Page/Page column 170 ;
Route2
- 3511-19-1
- 17356-08-0
- ~%
- In-stock
  
  105773-93-1
References
- Reppe et al. Justus Liebigs Annalen der Chemie, 1955 , vol. 596, p. 1,117

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 59.14
LogP 0.2601
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Aromatic heterocycle compounds Thiazole compounds

Key Words

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2-Amino-5-(2-hydroxyethyl)thiazole

CAS No. 105773-93-1

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