Lot numbers can be found on the outside label of a product:
6-Amino-4-chloronicotinic acid
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CAS No. 1060808-94-7
- Cat. No. CS-0105466
- Purity≥97%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 1060808-94-7
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General Information
- CAS No. 1060808-94-7
- Cat. No. CS-0105466
- Purity ≥97%
- MDL No. None
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₅ClN₂O₂
- Molecular Weight 172.57
- Synonym(s) α-D-Glucopyranuronicacid,methylester,2,3,8-triacetate
- SMILES O=C(C1=C(Cl)C=C(N)N=C1)O
Description
6-Amino-4-chloronicotinic acid is a bench-stable, electron-rich heterocyclic building block featuring a para-chloro and ortho-amino substitution on the pyridine ring. This combination enables direct coupling in medicinal chemistry workflows, particularly for synthesizing kinase inhibitors and bioactive scaffolds requiring polar, nitrogen-containing motifs.
Application
6-Amino-4-chloronicotinic acid serves as a versatile building block in the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-functionalized pyridine core enables selective transformations, including coupling reactions and cyclizations, while the amino and chloro groups offer complementary reactivity for sequential derivatization. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for scalable medicinal chemistry campaigns.
Synthesis
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Route1
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In-stock
670253-38-0 - ~81%
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In-stock
1060808-94-7
References
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BIOTA EUROPE LTD; TYNDALL, Edward Malcolm; CZAPLEWSKI, Lloyd George; FISHWICK, Colin William Gordon; YULE, Ian Andrew; MITCHELL, Jeffrey Peter; ANDERSON, Kelly Helen; PITT, Gary Robert William Patent: WO2013/91011 A1, 2013 ; Location in patent: Page/Page column 64; 65 ;
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Route2
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In-stock
19798-80-2 - ~%
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In-stock
1060808-94-7
References
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BIOTA EUROPE LTD; TYNDALL, Edward Malcolm; CZAPLEWSKI, Lloyd George; FISHWICK, Colin William Gordon; YULE, Ian Andrew; MITCHELL, Jeffrey Peter; ANDERSON, Kelly Helen; PITT, Gary Robert William Patent: WO2013/91011 A1, 2013 ;
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Route3
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In-stock
670253-37-9 - ~%
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In-stock
1060808-94-7
References
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BIOTA EUROPE LTD; TYNDALL, Edward Malcolm; CZAPLEWSKI, Lloyd George; FISHWICK, Colin William Gordon; YULE, Ian Andrew; MITCHELL, Jeffrey Peter; ANDERSON, Kelly Helen; PITT, Gary Robert William Patent: WO2013/91011 A1, 2013 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 76.21
- LogP 1.0154
- H_Acceptors 3
- H_Donors 2
- Rotatable_Bonds 1
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Key Words
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