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Structure of 106877-30-9
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3-Methyl-2-(trifluoromethyl)aniline features a trifluoromethyl group that imparts enhanced electron-withdrawing character and metabolic stability, while the methyl substituent provides steric influence. This combination enables efficient integration into pharmaceutical intermediates and advanced organic synthesis, particularly in the development of bioactive molecules requiring high lipophilicity and resistance to oxidative degradation.
3-Methyl-2-(trifluoromethyl)aniline serves as a valuable building block in medicinal chemistry and agrochemical synthesis, offering enhanced metabolic stability and lipophilicity due to the trifluoromethyl group. The ortho-trifluoromethyl and meta-methyl substituents provide directed functionalization potential, enabling efficient C–H activation and coupling reactions. Bench-stable and readily purified by column chromatography, it functions effectively in Suzuki-Miyaura, Ullmann, and electrophilic substitution protocols, facilitating access to complex heterocyclic scaffolds and pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: