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tert-Butyl 3-(aminomethyl)indoline-1-carboxylate

  • CAS No. 1086392-24-6

  • Cat. No. CS-0107291
  • Molecule weight248.32
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 3-(aminomethyl)indoline-1-carboxylate|CS-0107291

Structure of 1086392-24-6

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General Information

  • CAS No. 1086392-24-6
  • Cat. No. CS-0107291
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₀N₂O₂
  • Molecular Weight 248.32
  • Synonym(s) 3-Aminomethyl-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester
  • SMILES O=C(N1CC(CN)C2=C1C=CC=C2)OC(C)(C)C

Description

tert-Butyl 3-(aminomethyl)indoline-1-carboxylate features a protected amine and indoline scaffold, enabling direct incorporation into bioactive molecule synthesis. The tert-butyl carbamate group offers stability and convenient deprotection under mild acidic conditions. This building block integrates efficiently into peptidomimetics and kinase inhibitors, delivering enhanced solubility and metabolic resistance in drug discovery workflows.

Application

tert-Butyl 3-(aminomethyl)indoline-1-carboxylate serves as a versatile building block for indoline-based scaffolds in medicinal chemistry. The protected amine and carboxylate functionalities enable sequential functionalization, while the tert-butyl group offers stability and ease of removal under mild acidic conditions. It facilitates efficient synthesis of bioactive indolines via standard coupling, reduction, or cyclization protocols.

Safety Information

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Computational Chemistry Data

  • TPSA   55.56
  • LogP   2.484
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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