tert-Butyl 6-(aminomethyl)-2-azaspiro[3.3]heptane-2-carboxylate

Name: tert-Butyl 6-(aminomethyl)-2-azaspiro[3.3]heptane-2-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 1363380-79-3
Cat. No. CS-0048174
Purity≥97%
MDL No.MFCD22419342

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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tert-Butyl 6-(aminomethyl)-2-azaspiro[3.3]heptane-2-carboxylate|CS-0048174

Structure of 1363380-79-3

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Description

tert-Butyl 6-(aminomethyl)-2-azaspiro[3.3]heptane-2-carboxylate features a rigid spirocyclic core with a primary amine handle, enabling direct functionalization in medicinal chemistry. The tert-butyl ester group offers stability and convenient deprotection under mild acidic conditions. This scaffold integrates seamlessly into bioactive molecule design, particularly for constrained peptidomimetics and targeted kinase inhibitors.

Application

tert-Butyl 6-(aminomethyl)-2-azaspiro[3.3]heptane-2-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry and process development, enabling efficient access to constrained nitrogen-containing heterocycles. The protected amine and carboxylate functionalities offer orthogonal reactivity, facilitating sequential derivatization. Bench-stable and readily purified by standard chromatography, it functions as a key building block in the synthesis of bioactive molecules via amide coupling, reductive amination, or cyclization strategies.

General Information

CAS No. 1363380-79-3
Cat. No. CS-0048174
Purity ≥97%
MDL No. MFCD22419342
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₂₂N₂O₂
Molecular Weight 226.32
Synonym(s) None
SMILES O=C(OC(C)(C)C)N1CC2(C1)CC(CN)C2

Computational Chemistry Data

TPSA 55.56
LogP 1.5922
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Skeleton Aliphatic heterocycle compounds Azetidine compounds

Building Blocks Skeleton Fatty ring compounds Cyclobutane compounds

Building Blocks Skeleton Spirol Rings compounds

Key Words

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tert-Butyl 6-(aminomethyl)-2-azaspiro[3.3]heptane-2-carboxylate

CAS No. 1363380-79-3

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