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CS-W001157 4
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(1S,6R)-6-Amino-2,2-difluorocyclohexan-1-ol

  • CAS No. 1109284-40-3

  • Cat. No. CS-0618850
  • Molecule weight151.15
  • Purity≥98%
  • MDL No.MFCD29764238

*For research and further manufacturing use only, not for direct human use.

(1S,6R)-6-Amino-2,2-difluorocyclohexan-1-ol|CS-0618850

Structure of 1109284-40-3

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General Information

  • CAS No. 1109284-40-3
  • Cat. No. CS-0618850
  • Purity ≥98%
  • MDL No. MFCD29764238
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁F₂NO
  • Molecular Weight 151.15
  • Synonym(s) None
  • SMILES O[C@@H]1C(F)(F)CCC[C@H]1N

Description

This chiral cyclohexanol features a strategically positioned amino group and two fluorine atoms that enhance metabolic stability and influence conformational preferences. The (1S,6R) stereochemistry ensures precise spatial orientation for targeted interactions in medicinal chemistry applications.

Application

(1S,6R)-6-Amino-2,2-difluorocyclohexan-1-ol serves as a versatile chiral building block in medicinal chemistry, enabling access to fluorinated cyclohexane scaffolds prevalent in bioactive molecules. Its functional group tolerance supports diverse transformations, including derivatization of the amino and hydroxyl moieties. The molecule exhibits bench stability and facilitates efficient purification, making it well-suited for iterative synthesis campaigns and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   0.4938
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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