tert-Butyl 2-(piperazin-1-yl)acetate

Name: tert-Butyl 2-(piperazin-1-yl)acetate
Brand: ChemScene
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CAS No. 112257-22-4
Cat. No. CS-0154829
Purity≥97%
MDL No.MFCD06659535

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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tert-Butyl 2-(piperazin-1-yl)acetate|CS-0154829

Structure of 112257-22-4

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Description

tert-Butyl 2-(piperazin-1-yl)acetate features a piperazine ring tethered to a tert-butyl ester, delivering a robust, bench-stable scaffold for medicinal chemistry. The electron-rich piperazine moiety facilitates hydrogen bonding and solubility enhancement in drug discovery campaigns. This versatile building block integrates readily into diverse molecular architectures via orthogonal deprotection strategies.

Application

tert-Butyl 2-(piperazin-1-yl)acetate serves as a versatile building block in medicinal chemistry, enabling the efficient introduction of piperazine moieties into target molecules. The tert-butyl ester group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. It functions as a reliable precursor for bioactive scaffolds, particularly in kinase inhibitors and CNS-targeted compounds, with high functional group tolerance and compatibility in standard coupling protocols.

General Information

CAS No. 112257-22-4
Cat. No. CS-0154829
Purity ≥97%
MDL No. MFCD06659535
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₂₀N₂O₂
Molecular Weight 200.28
Synonym(s) Tert-butyl2-(piperazin-1-yl)acetate
SMILES CC(C)(C)OC(=O)CN1CCNCC1

Computational Chemistry Data

TPSA 41.57
LogP 0.2333
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Key Words

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tert-Butyl 2-(piperazin-1-yl)acetate

CAS No. 112257-22-4

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